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Thus, for a number of them, even if they are good substrates in vitro , other clearance pathways may be more important in vivo or, if they are cleaved by DPP-4, removal of the N-terminal dipeptide may have no effect upon their biological activity

Santini, S

By increasing fat intake and severely reducing carb intake, the keto diet attempts to switch the bodys main energy source from glucose to fat

Other parts might have virtually no preservative at all, rendering them no better than sterile water and susceptible to bacterial growth

doi: 10.1038/nature03354 49

Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse